NEW ENGLAND DRUG METABOLISM DISCUSSION GROUP

PRESENTATIONS

ARCHIVE

2019
Summer Symposium – 12 June, 2019
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“Fulfilling the Promise of Cell Therapies: Preclinical to Clinical Transition” (Meghan M. Flaherty, Ph.D., DADB) – Fulfilling the Promise of Cell Therapies (1.7MB)

Advancing Product Analytics for CAR T Cell Therapies” (Qiong (Chelsea) Xue) – Qiong_Xue.pdf (584 KB)

“ADME and PK/PD Considerations for Antisense Oligonucleotide Therapeutics” (Xiao Shelley Hu, Ph.D.) – ADME_andPKPD_Considerations.pdf (888 KB)

Spring Meeting – 27 March, 2019
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2018
Summer Symposium – 20 June, 2018
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“Essential Teachings of Steve Tannenbaum as Applied in ADME Sciences” (Ginping Gan, Ph.D.) – EssentialTeachings_of_SteveTannenbaum.pdf (2.64MB)

Spring Meeting – 15 March, 2018
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2017
Fall Dinner Meeting – 13 September, 2017
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“Recent Advances in Drug Transporter and Enzymology Sciences to Enable Drug Design” (Larry Tremaine) – Larry_Tremaine.pdf (2.8MB)

Summer Joint Symposium (NEDMDG & IQ-DMLG) – 31 May, 2017
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“Quantifying and communicating Uncertainty in Human PK and Dose Prediction” (Douglas Ferguson) – Ferguson.pdf (635KB)

“Use of Target Tissue Concentrations in PK-PD Modeling of Inhaled Drugs” (Ramon Hendrickx) – Hendrickx.pdf (1.03MB)

“How Systems Biology Can Advance Immune Oncology” (Birgit Schoeberl, Ph.D.) Schoeberl.pdf (1.31MB)

“Why Don’t Xenografted Tumourmodels translate to Patients?” (Dr. James Yates) Yates.pdf (1.02MB)

Spring Meeting – 8 March, 2017
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“Drug Disposition in Non-Alcoholic Fatty Liver Didease: Implications for Therapeutics and Drug Development (Rommel G. Tirona, Ph.D.) – Tirona_NEDMDG030817.pdf (4.3MB)

2016
Summer Symposium – 13 June, 2016
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“Qualification of New Translational Safety Biomarkers for Drug Development” (Warren Glaab) – NEDMDG_Meeting_Boston_Glaab_Jun16.pdf (625KB)

“Discovery of Endogenous Biomarkers for Organic Anion Transporter-mediated Drug-Drug Interactions” (Sook Wah Yee) – NEDMDG_YeeSW_v2.pdf (8.4MB)

Spring Meeting – 9 March, 2016
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2015
Winter Meeting – 2 December, 2015
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“Time Depending Inhibition With Atypical Kinetics, What Is One To DO?” (Ken Korzekwa) – KorzekwaTDI120215.pdf (5.72MB)

Fall Dinner Meeting – 16 September, 2015
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“Endogenous Probes for Drug-Metabolizing Enzymes and Transporters: Where are we now?” (A. David Rodrigues, Ph.D.) – RODRIGUES_NEDMDG_0915.PDF (3.9MB)

Summer Symposium – 11 June, 2015
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“DATA, DATA, DATA: Is There Something Else in In Silico ADME?” (Franco Lombardo, Ph.D.) – NEDMDG_flombardo_06112015.pdf (2.4MB)

“Decision-Making with Predictive ADME Data in Context of Experimental Variability” (Brian Mattioni, Ph.D.) – NEDMDG_Mattioni_CompADME_v1.pdf (1.5MB)

“Emerging In Vitro Culture Technologies to Address Challenges in Hepatic Metabolism and Drug Interactions” (Edward L. LeCluyse, Ph.D.) – LeCluyseNEDMDGseminar.pdf (913KB)

Spring Meeting – 11 March, 2015
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“The Importance of Concept of Fraction of Drug Transported (ft) in Understanding and Predicting Drug Disposition and DDI” (Jashvant (Jash) D. Unadkat, Ph.D.) – UnadkatNEDMG031015.pdf (3.2MB)

2014
Winter Meeting – 3 December, 2014
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Fall Meeting – 10 September, 2014
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“Are We Getting the Best Return on Investment from Drug-Drug Interaction Studies?” (Lawrence J. Lesko,Ph.D.) – Lesko NEDMG presentation Sept2014.pdf (4.1MB)

Summer Meeting – 19 May, 2014
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Spring Meeting – 12 March, 2014
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2013
Fall Meeting – 11 September, 2013
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“Imaging Mass Spectrometry: Molecular Mapping Beyond the Microscope” (Richard M. Caprioli, Ph.D.) – NEDMDG_Caprioli_Presentation_Sept2013.pdf (4.95MB)

Summer Meeting, 4 June, 2013
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“Plasma Protein Binding: Friend or Foe in Drug Discovery” (Kevin Beaumont, Tristan Maurer) – NEDMDG_PPBpresentation_2.pdf (1MB)

“Do We Need to Optimize Protein Binding in Drug Discovery?” (Xingrong Liu) – ProteinBinding_Liu_6_4_2013.pdf (1.24MB)

2012
Winter Meeting, 6 December, 2012
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“Cytokine-Dependent Regulation of Drug Metabolizing Enzymes as the Basis of Drug Interactions Between Therapeutic Proteins and small Molecules” – This presentation is availbale upon request from Dr. Morgan (email: etmorga@emory.edu)

Fall Dinner Meeting, 12 Sep, 2012
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“PBPK-Based Predictions of Drug-Drug Interactions: Examples and Applications” (Edgar Schuck) – Schuck_PBPK-BasedPredictions.pdf (1.4MB)

Summer Symposium, 13 June 2012
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“Evolving Trends in Complex Culture Systems and their Utility in Drug Development: Focus on hepatotoxicity” (N. Shangari) – Evolving_Trends_inComplexCultureSystems.pdf (1.6MB)

“Humanized Animal Models for Next Generation Translational Research” (J. Bial) – J.Bial_humanized_animal_models.pdf (1.34MB)

“Evaluation of Chimeric Mice with Humanized Liver to Predict Human Intrinsic Clearance of Drug Molecules at Preclinical Phase” (T. Bohnert) – T.Bohnert_Chimeric_Mice.pdf (602KB)

2011
Winter Meeting, 7 Dec, 2011
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“Mechanism-based Risk Assessment in Drug Development” – BAST_2011_12_07.pdf (1MB)

Fall Dinner Meeting, 21 Sep, 2011
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“What’s all the Flux About?: An Industry Perspective on the Drug Transporter Whitepaper and Recent Regulatory Guidances” – Polli_Whats_all_the_Flux_About.pdf (1.2MB)

Summer Symposium, 14 June 2011
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PBPK Modelling and its Applications to Predict Transporter-Mediated
Drug-Drug Interactions – M_Jamei_PBPK_and_Transporters_DDI.pdf (2.1MB)

The In Silico Child: PK/PD Modeling in Pediatric Drug Development- Meibohm.pdf (1MB)

Integrated Quantitative Modeling Approaches to Facilitate Drug Development Decisions – QS-Handout.pdf (696KB)

Spring Meeting, 2 Mar 2011
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Mechanisms of Idiosyncratic Drug Reactions and Their Implications for Risk Prediction – NEDMDG_mar2011_uetrecht.pdf (3.4MB)

2010
Winter Meeting, 1 Dec, 2010
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Fall Dinner Meeting, 22 Sep, 2010
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Deuteration of Drugs for Pharmacokintic Enhancement: Considerations Essential for Success – NEDMDGSept2010Vaz.pdf (400KB)

Summer Symposium, 9 June, 2010
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Development of DPP-4 Inhibitors as Antidiabetic Agents – DPP4.pdf (4.8MB)

Improving the Decision-Making Process in the Structural Modification of Drug Candidates (parts 1 & 2) – AK_NEDMDG_2010_Final.pdf (860KB)

Drug-Drug Interactions Between Small Molecules and Bioltherapeutics – NEDMDG_9June2010LKlunk.pdf (4.55MB)

Metabolic Activation and Idiosycratic Drug Toxicity: By Avoiding Structural Alerts, Do We Mitigate Risks? – NEDMDG-2010-Kalgutkar.pdf (4.63MB)

Spring Meeting, 3 Mar 2010
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Drug Transporters: Report from the International Transporter Consortium; Decisions, Impact and Future Directions – donald-tweedie.pdf (1.5 MB)

2009
Winter Meeting – 2 December, 2009
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Summer Symposium, 10 Jun 2009
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Approaches to Mitigating the Bioactivation Potential of Compounds in Lead Optimization – deepak-dalvie.pdf (2.63MB)

Time Dependent CYP Inhibition in Drug Discovery and Development – scott-grimm.pdf (14.76MB)

Prediction of Drug Metabolism: In Silico and Laboratory
Perspectives from Two Different Angles – lombardo-dennehy.pdf (2.2 MB)

Influence of therapy duration on suppression of emergence of resistance and influences of granulocytes on cell kill – george-drusano.pdf (1.69MB)

Winter Meeting, March 11, 2009
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2008
Fall Dinner Meeting, 10 Sep 2008

Metabolites and Safety: Diligence on Safety – Expedience for Patients – scott-obach.pdf (124KB)

Summer Symposium, 4 Jun 2008

Biomarkers and Translational Medicine – donna-mendrick.pdf (3.86 MB)

Novel Translational Biomarkers – peter-obrien.pdf (2.53MB)

Regulatory Application of Quantitative Analysis: Impact of Biomarker Data – yaning-wang.pdf (9MB)

Application of PK/PD Modeling for Developing and Evaluating Rational Strategies for Optimizing Therapy with Mabs – joseph-balthasar.pdf (0.60MB)

Using Biomarkers for Early Phase Dose Selection with Protein Antagonist Drugs – ivan-nestorov.pdf (1.12MB)

Spring Meeting, 12 Mar 2008

The Economics of New Drug Development:
Costs, Risks and Returns – joseph-dimasi-spring-2008.pdf (1.3MB)

2007
Dinner Meeting, 5 Dec 2007

In Vitro to In Vivo Predictions of Drug Interactions: Going Beyond the I/Ki Ratio – jash-unadkat.pdf (1.2MB)

Gerald Miwa Retirement Symposium, 9 Apr 2007

DMPK in drug industry: The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transporters – anthony-lu.pdf (2.1MB)

SUSTIVA: Uncovering the mechanism for the metabolism-dependent, species-selective nephrotoxicity – david-christ.pdf (0.5MB)

DM/PK-guided lead optimization: A historical perspective of a paradigm shift – dhiren-thakker.pdf (0.6MB)

P450 reactions: The basic, the exotic and the important
fred-guengerich.pdf (3MB)

Memories from a career – gerald-miwa.pdf (3.6MB)

Heme: the catalytic center and a target in hemoproteins
paul-ortiz.pdf (1.16MB)

Predicting DMPK of NMEs: What Do We Need in Terms of Science and Tools? – leslie-benet.pdf (0.6MB )

Human Metabolism of a Novel Chemotherapeutic: Illuminating the Mechanisms of P450-Catalyzed Deboronation – scott-daniels.pdf (0.6MB)

2006

Fall Dinner Meeting

Current perspectives on Rapid INDs – mitch-cayen.pdf (174KB)

Spring Dinner Meeting, March 2006

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PK/PD Modeling and Simulation for Compound Progression of Antiretroviral Agents – jeffrey-barrett.pdf (1.4MB)

Statistical spectroscopy and global systems biology approaches in disease modeling – jeremy-nicholson.pdf (3.72MB)

Small Molecule Analysis Using Diverse Separation Techniques Coupled to MicroelectrosprayMass Spectrometry – paul-vouros.pdf (1.37MB)

Ionization Methods in MS – graham-cooks.pdf (3.84MB)

2005

Winter Meeting , December 2005

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Targeted Bioavailability – Mechanisms of Drug Tissue Distribution – elmquist.pdf (9.8MB)

Hepatic Drug Transport – hoffmaster.pdf (2MB)

PGx of Drug-Transporter Interactions – sadee.pdf (1.6MB)

HT Approaches to AMS – skipper.pdf (1.25MB)

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