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R2622188 Principal Scientist, DMPK Sanofi (Posted January 6th, 2022)

Company: Sanofi

Location: Waltham, MA (Jan-June) then Cambridge, MA, USA (from July onward)

Job Description: Principal Scientist

Company Overview

At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into
breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and
inclusive workforce – and workplace – which brings together the collective brainpower of over 2,000
colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we
deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.

Position Overview

Sanofi is seeking an energetic and self-motivated scientist to join the Drug Metabolism and
Pharmacokinetics (DMPK) research platform of the North American Hub. As a member of the DMPK
department you will join a team of DMPK scientists to support the discovery projects in the therapeutic
areas of Rare and Neuro Diseases, Rare Blood Disorders, Immunology and Inflammation, and Immunooncology.

Key Responsibilities:

Evaluate and monitor in vitro ADME outsourcing activities at CROs, including but not limited to metabolism,
protein binding, tissue partitioning, and drug-drug interaction. Perform complex data analysis for
interpreting ADME properties for establishing in vitro-in vivo correlations and translation to human. Manage
CROs for in vitro assays to characterize enzyme kinetics, reaction phenotyping, and drug-drug interaction
potential for potential small molecule clinical candidates. Develop and execute novel cell-based assays to
investigate non-routine issues when applicable. Develop tools and design in vivo experiments to enable
the investigation of ADME related project issues. Promote innovative approaches for the advancement of
drug candidates across various modalities including small molecules, RNA, and biotherapeutics.
Approaches to innovative computational ADME is a plus.
The role also includes the review of reports generated from CROs and the preparation of study reports for
regulatory submissions. Highly qualified candidates may also be provided the opportunity to represent
DMPK on project teams.

Basic Requirements:

  • A Ph.D. in Drug Metabolism or Pharmacokinetics with 5+ years of relevant post-graduate
  • Ability to independently conduct in vitro ADME studies, propose and/or generate new tools to
    address metabolism and other ADME issues.
  • Extensive knowledge of drug metabolism and pharmacokinetics in a research setting.
  • Ability to keep current with literature and report scientific data in a public forum.
  • Ability to initiate and implement new research ideas. Summarize research results into
    scientific presentation and manuscript.
  • Demonstrate strong written and verbal communication skills and have a solid scientific
    publication record.
  • Able to work in a collaborative environment and contribute to high scientific rigor.
  • Demonstrate ability to work in a matrix environment and in a global environment.

Apply by visiting:



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Senior / Principal Scientist, DMPK Relay Therapeutics

Company: Relay Therapeutics

Location: Cambridge, MA, USA 

Job Description: Senior / Principal Scientist, DMPK

The Opportunity:

Are you a versatile and self-motivated scientist who looks to advance drug discovery programs towards the clinic?  Then we’re looking for you! You will have an opportunity to join a growing DMPK team and be a functional lead on assigned project teams developing small molecule modulators of clinically meaningful and validated targets in cancer and genetic diseases. We are looking for a consummate teammate who seeks a scientifically rigorous and collaborative environment with huge potential for growth and learning.

Your Role: 

  • You will be the functional area representative for DMPK on multidisciplinary project teams.
  • You will design and execute a broad array of in silico, in vitro and in vivo DMPK studies to drive program progression and decision making.
  • You will collaborate internally across all disciplines as well as manage experimental work at CRO partners.
  • You’ll play a part in enhancing DMPK approaches to supporting drug discovery. 

Your Background: 

  • You have a PhD with exposure to DMPK-related research or relevant postdoctoral experience.
  • You are scientifically curious and rigorous, and are driven to learn.
  • You’re comfortable navigating complexity and ambiguity in an environment that is constantly changing.
  • You’re an articulate, open communicator (both oral and written) with the ability to analyze, interpret and present data in a clear manner. 

About Relay Therapeutics

Relay Therapeutics is a clinical-stage precision medicines company transforming the drug discovery process with the goal of bringing life-changing therapies to patients. Built on unparalleled insights into protein motion and how this dynamic behavior relates to protein function, we aim to effectively drug protein targets that have previously been intractable, with an initial focus on enhancing small molecule therapeutic discovery in targeted oncology. Our Dynamo platform integrates an array of leading-edge experimental and computational approaches to provide a differentiated understanding of protein structure and motion to drug these targets. We have built a world-class team of leading experts from each of these disciplines, and they are driven by a deep collaboration at every step of our drug discovery process.  

Our team is equal parts fearless and relentless, with a shared passion for working collaboratively in intellectually stimulating environments. If you’re excited by the challenge of putting protein motion at the heart of drug discovery and passionate about making a difference in the lives of patients, join us! 

Company policy requires that all employees be fully vaccinated against COVID-19, and all new hires must be fully vaccinated (as defined by the CDC) by the time they start employment. By applying to this position, you are confirming that, if hired, you can satisfy this express condition of employment. The Company will make reasonable accommodations under applicable law for qualified individuals to enable them to perform the essential functions of the job, unless doing so would create an undue hardship for the Company.

Apply by visiting:



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Location: Murcia, Spain

Job Description: ADME Senior Scientist

EUROFINS VILLAPHARMA is seeking an ADME Senior Scientist based in Murcia (Spain) with a strong experience in and understanding of absorption, distribution, metabolism and excretion (ADME) of drugs and related toxicology.

EUROFINS VILLAPHARMA is expanding its footprint with the opening of a new research Centre in early 2021 to serve the growing market of outsourced drug discovery with its high quality chemistry capabilities. That person will play a pivotal role in maintaining a productive a collaborative working environment.

The position comprises mainly of designing and directing the in vitro metabolism assay panel we perform for our customers, instructing and supporting laboratory technicians and scientist in their experiments, processing and interpreting the experimental data into results and reports, and communicating with our customers.


  • Responsible for performing and reporting in vitro metabolism ADME studies for discovery stage compounds.
  • Actively participate in experimental design, perform experiments as well as critically analyse, interpret and report the data to design next steps.
  • Ability to perform high-impact as well as high throughput studies to completion in a fast paced environment, while managing multiple projects to meet the timelines.
  • Provides scientific knowledge and responsible in establishing new ADME assays as well as contribute to the continuous improvement of the current ADME assays
  • Perform Quality Review of peer data and assist in consolidating assay control and validation criteria.
  • Ensure work is conducted within set timeframes and to the highest scientific and regulatory standards.


We are looking for a professional with these required skills:

  • BS/MS in a scientific relevant field with at least 2 years of related experience in contract research organizations, pharmaceutical industries or academia. (Ph.D. preferred).
  • Industry/academic experience in DM/PK with solid understanding of pharmacology and ADME concepts.
  • Knowledge of bioanalytical sciences including LC-MS/MS, GC-MS, and physical organic chemistry.
  • Experienced in cell based or biochemical assays.
  • Ability to work in a team environment, remaining attentive to ideas, recognizing responsibilities, and actively participating with others to accomplish assignments and achieve desired goals.
  • Excellent oral and written communication skills.
  • Strong attention to detail.
  • Ability to manage time and works independently.
  • Experience working and influencing in a cross functional , matrix environment
  • Proven ability to manage a broad variety of projects and priorities.

Preferred Experience:

  • Extensive knowledge in synthetic organic chemistry, both theoretical and practical.
  • Experience in lead optimization, SAR analysis and drug design.
  • Experience in drug discovery/development.

Additional Information


– Immediate incorporation into a multinational group with strong growth.

– Good work environment, career plan, etc …

– Salary: Negotiable individually according to value and experience provided.

Apply by visiting linkedin site or contact:

Ginés Nieto:

Telephone: +34 968 197 524




If you are a scientist who is interested in participating in these meetings,then please provide your contact details below and we shall be in touch. Thank you.

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