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Director, Bioanalysis for B Cell Therapy

Company: Be Biopharma, Inc

Location: Cambridge, MA

Job Description:  Director of Bioanalysis for B Cell Therapy

Company Overview

Be Biopharma (“Be Bio”) is pioneering Engineered B Cell Medicines (BeCM) to dramatically improve patients’ lives who are living with cancer, rare diseases and other serious conditions. With eyes locked on the patient, our team of purpose-driven scientists, technologists, manufacturing experts and business builders collaborate to create a bold new class of cell therapies. Be Bio was founded in October 2020 by Longwood Fund and B cell engineering pioneers David Rawlings, M.D., and Richard James, Ph.D. from Seattle Children’s Research Institute. Be Bio is backed by ARCH Venture Partners, Atlas Venture, RA Capital Management, Alta Partners, Longwood Fund, Bristol Myers Squibb and Takeda Ventures. Since our founding, Be Bio’s investors have committed over $180 million to enable the Company to re-imagine medicine based on the power of B cell therapy. For more information, please visit us at Be.Bio and our LinkedIn page.

The beating heart of Be Bio is our People and together we are building a culture driven by purpose, passion, and that’s full of character.  We are “all-in” as we align ourselves with patients who need our medicines, and we embrace the highest standards of transparency, excellence, candor, collaboration, and team-based science with a shared ownership of company milestones and successes. 

Our commitment to our team members is to deliver a compelling, dynamic work experience that enables them to continually stretch, grow, and learn, that enriches their lives, that fosters a sense of belonging and community, and that goes above and beyond to support them in big, meaningful ways in both their personal and professional lives.  Be Bio is a team that works hard, plays hard, and supports each other on our shared journey to get transformative medicines to patients who need them. 

Position Overview:

The Director of Bioanalysis for B Cell Therapy is responsible for building and leading a team of scientists to develop bioanalytical plans and be involved in the design, development, qualification, and validation of quantitative assays supporting B cell therapy research and development. This is an exciting opportunity at Be Bio, which is creating a bold new class of cell therapies and is advancing B cell therapy to clinic.

Job Responsibilities

  • Build up our bioanalytical capability to support B cell therapy programs at both research and development stages
  • Builds and retains a team of high-performing scientists & RAs that can realize the company’s goals
  • Act as the subject matter expert (SME) in protein assays (e.g., LC-MS, ELISA), molecular assays (e.g., qPCR, ddPCR etc.), and cellular assays (e.g., flow cytometry, ELISpot etc.) development, qualification, and validation
  • Be involved in the design, development, qualification, and validation of quantitative assays supporting B cell therapy programs from research to clinic.
  • Develop internal guidelines for bioanalytical method development and ruggedness evaluation of assay in support of in vivo studies
  • Identify CROs, oversee method development in house or at identified CROs, method transfer and method validation at CROs. Ensures bioanalytical method development is performed with a level of rigor and validation appropriate for stage of research and development ensuring compliance with internal guidelines, SOPs and regulatory guidelines.
  • Review data for scientific rigor and ensure project compliance with external regulatory requirements and internal guidelines
  • Review and approve method qualification/validation reports and sample analysis reports.
  • Drive innovation within Bioanalysis and keep up to date of new technologies and instrumentation for implementation of new experimental strategies.
  • The ability to deliver clear, concise, and persuasive oral, and written communications is required.
  • Key interdepartmental collaborations will include Research, Technical Operation, and Clinical group to ensure adequate and timely bioanalytical support of non-GLP and GLP preclinical and clinical studies.
  • Maintain and support safe lab practices and environment.

Experience, Education, Specialized Knowledge, and Skills:

Must thrive in a fast-paced, growing, and innovative environment where flexibility, resourcefulness, resiliency, and communication skills are key. Excellent interpersonal skills, ability to develop important relationships with your stakeholders, and being an all-around good company citizen are essential. Demonstrated ability to manage a high-performing team where collaboration and innovation are essential. 

  • Ph.D. or Master’s degree in biology, immunology, chemistry, pharmacology, or related scientific fields required with 10+ years’ relevant experience.
  • Demonstrated experience and expertise in developing and establishing bioanalytical methods to support cell and gene therapy programs
  • Strong background in protein assays (e.g., LC-MS, ELISA), molecular techniques (qPCR, ddPCR etc.) and cellular assays such as flow cytometry, ELISpot etc.
  • Knowledge of current regulatory guidance and industry best practices in cell and gene therapy bioanalysis
  • Familiar with requirements of FDA/EMA, GLP/GCLP regulations, and ICH guidelines.
  • Great leadership experience in both project and people management is required.
  • Ability to achieve objectives/timelines through collaborative efforts with coworkers, managers, and CROs.
  • Ability to work independently and have good attention to the details.
  • Background in B cell biology/immunology highly desirable

How to apply:

Apply through Job page link below: 




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345447BR Novartis Biotransformation Scientist, PK Sciences

Company: Novartis

Location: Cambridge, MA

Job Description: Biotransformation Scientist

Company Overview

766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.
We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.
We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what’s possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Position Overview:

100,000 + people across 140 countries are working for Novartis to discover, develop and successfully market innovative products to prevent and cure diseases, to ease suffering, and to enhance the quality of life!

Biotransformation is a key discipline within the Drug Disposition (DD) unit of the Pharmacokinetic Sciences (PKS) department that is essential for the progression of small molecules and new modalities such as drug-protein conjugates, oligonucleotides, peptides and radio-ligands from preclinical discovery into human and up to regulatory filing.

PKS is currently seeking a laboratory-based associate to join the biotransformation team in Cambridge, MA. In this role, you will be joining a large global team of skilled and motivated drug metabolism scientists who closely collaborate with other groups both within and outside of PKS in a highly cross-functional environment.

As the successful candidate you will be adaptable, independently motivated, and challenge driven with a history that demonstrates strong interpersonal skills that encourage successful collaborative working relationships. In this role, you will work in a team environment to support programs through the conduct of drug metabolism studies designed to understand ADME properties, biotransformation pathways, and routes of elimination for a diverse portfolio of therapeutic modalities. Your major responsibilities will include planning, conducting and documenting experiments designed to investigate metabolic pathways and structural elucidation of metabolites formed from new drug candidates using state of the art high resolution mass spectrometers.

PKS offers many opportunities to diversify your skills and develop your career. You will be encouraged to interact with and present your findings to project teams and will be given development opportunities to increase your project management skills including representing the ADME function on project teams and serving as a part-time project team manager.

Job Responsibilities
Your main accountabilities will include:
• Design and execution of biotransformation studies to assess metabolic pathways, soft-spot identification, structural elucidation, and bioactivation of drug candidates
• Organize and prepare experimental protocols and study reports with upload of results to a centralized database
• Presentation of key findings to project teams and/or other stakeholders
• Support discovery, pre-clinical, and clinical development studies (in vitro and in vivo) to aid drug candidate progression
• Assure quality standard guidelines and safe work practices are applied while working in the laboratories

Basic Requirements:

• Degree in Chemistry/Biochemistry/Biology/Pharmaceutical Sciences with experience in drug discovery, or a higher degree with research experience relevant to drug metabolism or mass spectrometry science
• PhD with 0+ years, MS with 0 – 5+ years, or BS with 5 – 10+ years of relevant experience
• Title and salary will be commensurate with experience

The ideal candidate will draw from any the following key skillsets:
• Familiarity with in vitro systems (hepatocytes, microsomes, S9 fraction, recombinant enzymes)
• Hands-on experience in operation, maintenance, and troubleshooting of state-of-the-art high resolution orbitrap and inductively coupled plasma mass spectrometers
• Experience with HPLC/UPLC, ion pairing and size exclusion chromatography
• Prior experience with either oligonucleotide and/or intact protein analysis is desired but not required
• Excellent oral and written communication skills
• Careful attention to detail, exceptional organizational skills and ability to multitask

Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Vaccine Policy: While Novartis does not require vaccination at this time, for certain Novartis sites in the US all associates and candidates may be required to either upload an image of their COVID-19 vaccine card demonstrating proof of full vaccination for COVID-19 (or other similar evidence of vaccination) or proof of a negative COVID-19 test taken by the associate or candidate within the past seven days to enter any of our sites and/or customer office or healthcare facility, as well as prior to participating in other work related off-site meetings. Employees working in customer-facing roles must adhere to and comply with customers’ (such as hospitals, physician offices, etc.) credentialing guidelines, which may require vaccination. As required by applicable law, Novartis will consider requests for reasonable accommodation for those unable to be vaccinated. This requirement is subject to applicable state and local laws and may not be applicable to employees working in certain jurisdictions. Please send accommodation requests to

How to apply:

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here:

Job page link:




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R2622188 Principal Scientist, DMPK Sanofi (Filled May, 2022)

Company: Sanofi

Location: Waltham, MA (Jan-June) then Cambridge, MA, USA (from July onward)

Job Description: Principal Scientist

Company Overview

At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into
breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and
inclusive workforce – and workplace – which brings together the collective brainpower of over 2,000
colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we
deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.

Position Overview

Sanofi is seeking an energetic and self-motivated scientist to join the Drug Metabolism and
Pharmacokinetics (DMPK) research platform of the North American Hub. As a member of the DMPK
department you will join a team of DMPK scientists to support the discovery projects in the therapeutic
areas of Rare and Neuro Diseases, Rare Blood Disorders, Immunology and Inflammation, and Immunooncology.

Key Responsibilities:

Evaluate and monitor in vitro ADME outsourcing activities at CROs, including but not limited to metabolism,
protein binding, tissue partitioning, and drug-drug interaction. Perform complex data analysis for
interpreting ADME properties for establishing in vitro-in vivo correlations and translation to human. Manage
CROs for in vitro assays to characterize enzyme kinetics, reaction phenotyping, and drug-drug interaction
potential for potential small molecule clinical candidates. Develop and execute novel cell-based assays to
investigate non-routine issues when applicable. Develop tools and design in vivo experiments to enable
the investigation of ADME related project issues. Promote innovative approaches for the advancement of
drug candidates across various modalities including small molecules, RNA, and biotherapeutics.
Approaches to innovative computational ADME is a plus.
The role also includes the review of reports generated from CROs and the preparation of study reports for
regulatory submissions. Highly qualified candidates may also be provided the opportunity to represent
DMPK on project teams.

Basic Requirements:

  • A Ph.D. in Drug Metabolism or Pharmacokinetics with 5+ years of relevant post-graduate
  • Ability to independently conduct in vitro ADME studies, propose and/or generate new tools to
    address metabolism and other ADME issues.
  • Extensive knowledge of drug metabolism and pharmacokinetics in a research setting.
  • Ability to keep current with literature and report scientific data in a public forum.
  • Ability to initiate and implement new research ideas. Summarize research results into
    scientific presentation and manuscript.
  • Demonstrate strong written and verbal communication skills and have a solid scientific
    publication record.
  • Able to work in a collaborative environment and contribute to high scientific rigor.
  • Demonstrate ability to work in a matrix environment and in a global environment.

Apply by visiting:



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Senior / Principal Scientist, DMPK Relay Therapeutics

Company: Relay Therapeutics

Location: Cambridge, MA, USA 

Job Description: Senior / Principal Scientist, DMPK

The Opportunity:

Are you a versatile and self-motivated scientist who looks to advance drug discovery programs towards the clinic?  Then we’re looking for you! You will have an opportunity to join a growing DMPK team and be a functional lead on assigned project teams developing small molecule modulators of clinically meaningful and validated targets in cancer and genetic diseases. We are looking for a consummate teammate who seeks a scientifically rigorous and collaborative environment with huge potential for growth and learning.

Your Role: 

  • You will be the functional area representative for DMPK on multidisciplinary project teams.
  • You will design and execute a broad array of in silico, in vitro and in vivo DMPK studies to drive program progression and decision making.
  • You will collaborate internally across all disciplines as well as manage experimental work at CRO partners.
  • You’ll play a part in enhancing DMPK approaches to supporting drug discovery. 

Your Background: 

  • You have a PhD with exposure to DMPK-related research or relevant postdoctoral experience.
  • You are scientifically curious and rigorous, and are driven to learn.
  • You’re comfortable navigating complexity and ambiguity in an environment that is constantly changing.
  • You’re an articulate, open communicator (both oral and written) with the ability to analyze, interpret and present data in a clear manner. 

About Relay Therapeutics

Relay Therapeutics is a clinical-stage precision medicines company transforming the drug discovery process with the goal of bringing life-changing therapies to patients. Built on unparalleled insights into protein motion and how this dynamic behavior relates to protein function, we aim to effectively drug protein targets that have previously been intractable, with an initial focus on enhancing small molecule therapeutic discovery in targeted oncology. Our Dynamo platform integrates an array of leading-edge experimental and computational approaches to provide a differentiated understanding of protein structure and motion to drug these targets. We have built a world-class team of leading experts from each of these disciplines, and they are driven by a deep collaboration at every step of our drug discovery process.  

Our team is equal parts fearless and relentless, with a shared passion for working collaboratively in intellectually stimulating environments. If you’re excited by the challenge of putting protein motion at the heart of drug discovery and passionate about making a difference in the lives of patients, join us! 

Company policy requires that all employees be fully vaccinated against COVID-19, and all new hires must be fully vaccinated (as defined by the CDC) by the time they start employment. By applying to this position, you are confirming that, if hired, you can satisfy this express condition of employment. The Company will make reasonable accommodations under applicable law for qualified individuals to enable them to perform the essential functions of the job, unless doing so would create an undue hardship for the Company.

Apply by visiting:



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Location: Murcia, Spain

Job Description: ADME Senior Scientist

EUROFINS VILLAPHARMA is seeking an ADME Senior Scientist based in Murcia (Spain) with a strong experience in and understanding of absorption, distribution, metabolism and excretion (ADME) of drugs and related toxicology.

EUROFINS VILLAPHARMA is expanding its footprint with the opening of a new research Centre in early 2021 to serve the growing market of outsourced drug discovery with its high quality chemistry capabilities. That person will play a pivotal role in maintaining a productive a collaborative working environment.

The position comprises mainly of designing and directing the in vitro metabolism assay panel we perform for our customers, instructing and supporting laboratory technicians and scientist in their experiments, processing and interpreting the experimental data into results and reports, and communicating with our customers.


  • Responsible for performing and reporting in vitro metabolism ADME studies for discovery stage compounds.
  • Actively participate in experimental design, perform experiments as well as critically analyse, interpret and report the data to design next steps.
  • Ability to perform high-impact as well as high throughput studies to completion in a fast paced environment, while managing multiple projects to meet the timelines.
  • Provides scientific knowledge and responsible in establishing new ADME assays as well as contribute to the continuous improvement of the current ADME assays
  • Perform Quality Review of peer data and assist in consolidating assay control and validation criteria.
  • Ensure work is conducted within set timeframes and to the highest scientific and regulatory standards.


We are looking for a professional with these required skills:

  • BS/MS in a scientific relevant field with at least 2 years of related experience in contract research organizations, pharmaceutical industries or academia. (Ph.D. preferred).
  • Industry/academic experience in DM/PK with solid understanding of pharmacology and ADME concepts.
  • Knowledge of bioanalytical sciences including LC-MS/MS, GC-MS, and physical organic chemistry.
  • Experienced in cell based or biochemical assays.
  • Ability to work in a team environment, remaining attentive to ideas, recognizing responsibilities, and actively participating with others to accomplish assignments and achieve desired goals.
  • Excellent oral and written communication skills.
  • Strong attention to detail.
  • Ability to manage time and works independently.
  • Experience working and influencing in a cross functional , matrix environment
  • Proven ability to manage a broad variety of projects and priorities.

Preferred Experience:

  • Extensive knowledge in synthetic organic chemistry, both theoretical and practical.
  • Experience in lead optimization, SAR analysis and drug design.
  • Experience in drug discovery/development.

Additional Information


– Immediate incorporation into a multinational group with strong growth.

– Good work environment, career plan, etc …

– Salary: Negotiable individually according to value and experience provided.

Apply by visiting linkedin site or contact:

Ginés Nieto:

Telephone: +34 968 197 524




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