New England Drug Metabolism Discussion Group
 
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Presentations

 

From the NEDMDG Symposia

2011

Winter Meeting, 7 Dec, 2011 - flyer

“Mechanism-based Risk Assessment in Drug Development” - BAST_2011_12_07.pdf (1MB)

Fall Dinner Meeting, 21 Sep, 2011 - flyer

“What’s all the Flux About?: An Industry Perspective on the Drug Transporter Whitepaper and Recent Regulatory Guidances” - Polli_Whats_all_the_Flux_About.pdf (1.2MB)

Summer Symposium, 14 June 2011 - flyer

PBPK Modelling and its Applications to Predict Transporter-Mediated
Drug-Drug Interactions - M_Jamei_PBPK_and_Transporters_DDI.pdf (2.1MB)

The In Silico Child: PK/PD Modeling in Pediatric Drug Development- Meibohm.pdf (1MB)

Integrated Quantitative Modeling Approaches to Facilitate Drug Development Decisions - QS-Handout.pdf (696KB)

Spring Meeting, 2 Mar 2011 - flyer

Mechanisms of Idiosyncratic Drug Reactions and Their Implications for Risk Prediction - NEDMDG_mar2011_uetrecht.pdf (3.4MB)


   

2010

 

Winter Meeting, 1 Dec, 2010 - flyer

Fall Dinner Meeting, 22 Sep, 2010 - flyer

Deuteration of Drugs for Pharmacokintic Enhancement: Considerations Essential for Success - NEDMDGSept2010Vaz.pdf (400KB)

Summer Symposium, 9 June, 2010 - flyer

Development of DPP-4 Inhibitors as Antidiabetic Agents - DPP4.ppt (7.55MB)

Improving the Decision-Making Process in the Structural Modification of Drug Candidates (parts 1 & 2) - AK_NEDMDG_2010_Final.ppt (1.4MB)

Drug-Drug Interactions Between Small Molecules and Bioltherapeutics - NEDMDG_9June2010LKlunk.ppt (6.16MB)

Metabolic Activation and Idiosycratic Drug Toxicity: By Avoiding Structural Alerts, Do We Mitigate Risks? - NEDMDG-2010-Kalgutkar.ppt (3.3MB)

Spring Meeting, 3 Mar 2010 - flyer

Drug Transporters: Report from the International Transporter Consortium; Decisions, Impact and Future Directions - donald-tweedie.pdf (1.5 MB)


   

2009

 

Winter Meeting - 2 December, 2009 - flyer

Summer Symposium, 10 Jun 2009 - flyer

Approaches to Mitigating the Bioactivation Potential of Compounds in Lead Optimization - deepak-dalvie.ppt (636 KB)

Time Dependent CYP Inhibition in Drug Discovery and Development - scott-grimm.ppt (408 KB)

Prediction of Drug Metabolism: In Silico and Laboratory
Perspectives from Two Different Angles - lombardo-dennehy.pdf (2.2 MB)

Winter Meeting, March 11, 2009 - flyer


   

2008

 

Fall Dinner Meeting, 10 Sep 2008
Metabolites and Safety: Diligence on Safety - Expedience for Patients - scott-obach.pdf (124 KB)

Summer Symposium, 4 Jun 2008
Biomarkers and Translational Medicine - donna-mendrick.pdf (3.86 MB)

Novel Translational Biomarkers - peter-obrien.pdf (2.53 MB)

Regulatory Application of Quantitative Analysis: Impact of Biomarker Data - yaning-wang.ppt (1.86 MB)

Application of PK/PD Modeling for Developing and Evaluating Rational Strategies for Optimizing Therapy with Mabs - joseph-balthasar.pdf (0.60 MB)

Using Biomarkers for Early Phase Dose Selection with Protein Antagonist Drugs - ivan-nestorov.ppt (1.71 MB)


Spring Meeting, 12 Mar 2008
The Economics of New Drug Development:
Costs, Risks and Returns -
joseph-dimasi-spring-2008.ppt (612 KB)



2007


















Download all presentations (10.60 MB, .zip)

Dinner Meeting, 5 Dec 2007
In Vitro to In Vivo Predictions of Drug Interactions:
Going Beyond the I/Ki Ratio -
jash-unadkat.pdf (1.20 MB)


Gerald Miwa Retirement Symposium, 9 Apr 2007
DMPK in drug industry: The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transporters - anthony-lu.pdf (2.10 MB)

SUSTIVA: Uncovering the mechanism for the metabolism-dependent, species-selective nephrotoxicity - david-christ.pdf (0.50 MB)

DM/PK-guided lead optimization: A historical perspective of a paradigm shift - dhiren-thakker.pdf (0.60 MB)

P450 reactions: The basic, the exotic and the important
-
fred-guengerich.pdf (3.00 MB)

Memories from a career - gerald-miwa.pdf (3.60 MB)

Heme: the catalytic center and a target in hemoproteins
- paul-ortiz.pdf (1.16 MB)


Predicting DMPK of NMEs: What Do We Need in Terms of Science and Tools? - leslie-benet.pdf (0.60 MB )

Human Metabolism of a Novel Chemotherapeutic: Illuminating the Mechanisms of P450-Catalyzed Deboronation - scott-daniels.pdf (0.60 MB)



2006
Principles of Drug Metabolism - A short course in Fall '06 - flyer

Fall dinner meeting

Current perspectives on Rapid INDs - mitch-cayen.ppt







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Spring Dinner Meeting , March 2006 - flyer

PK/PD Modeling and Simulation for Compound Progression of Antiretroviral Agents - jeffrey-barrett.pdf

Statistical spectroscopy and global systems biology approaches in disease modeling - jeremy-nicholson.ppt

Small Molecule Analysis Using Diverse Separation Techniques Coupled to MicroelectrosprayMass Spectrometry - paul-vouros.pdf

Ionization Methods in MS - graham-cooks.pdf




2005




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Winter Meeting , December 2005 flyer
* Now you can register online for the event!

Targeted Bioavailability - Mechanisms of Drug Tissue Distribution - elmquist.ppt

Hepatic Drug Transport - hoffmaster.pdf

PGx of Drug-Transporter Interactions - sadee.pdf

HT Approaches to AMS - skipper.pdf